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Accueil du site > Séminaires > Séminaires passés > Séminaire de Ralf Blossey le 31 janvier 2012 à l’IRI

Séminaire de Ralf Blossey le 31 janvier 2012 à l’IRI

Kinetic control of gene expression by chromatin remodeling

Ralf Blossey, PhD

Interdisciplinary Research Institute

Chromatin remodeling is the ATP-dependent change of chromatin structure performed by dedicated motor complexes acting on nucleosomal substrates. I give a general introduction into chromatin remodeling and discuss a general mechanism through which the remodelers are targeted to their substrates. This so-called ”kinetic proofreading scenario” has recently found experimental support for the ISWI-family of remodelers which lead to repressed chromatin states. In this context I also discuss the role of ISWI remodelers for nucleosome positioning.

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Ralf Blossey - 2012/01/31
IRI - USR3078