Ralf Blossey, PhD
Interdisciplinary Research Institute
Chromatin remodeling is the ATP-dependent change of chromatin structure performed by dedicated motor complexes acting on nucleosomal substrates. I give a general introduction into chromatin remodeling and discuss a general mechanism through which the remodelers are targeted to their substrates. This so-called ”kinetic proofreading scenario” has recently found experimental support for the ISWI-family of remodelers which lead to repressed chromatin states. In this context I also discuss the role of ISWI remodelers for nucleosome positioning.
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